Tamoxifen Bodybuilding PCT Does Nolvadex Cause Gyno Issues?

When it acts in an estrogenic fashion in the liver for instance, tamoxifen can increase levels of sex hormone binding globulin (SHGB) which acts to bind to testosterone thus lowering free testosterone in the body. Free testosterone is the amount of unbound testosterone in the system and it is the level of free testosterone which is strongly correlated to the positive effects of high testosterone such as increased muscle mass, strength, and libido. This article will go into some of the details on why Tamoxifen has been recommended for bodybuilders, as well as some side effects that most people fail to understand before embarking on the use of this compound. Carcinogenic action – Tamoxifen has been shown in several studies 4,5,6) to increase the risk of cancer and is listed as a known carcinogen by the American Cancer Society. Studies in rats (7) add further weight to the argument supporting tamoxifen’s carcinogenic potential with up to 80% of animals developing malignant tumours.

• Considering that the subjects in this trial used tamoxifen at a lower dose of just 10mg it begs the question of what would happen if used at the higher dosage typically seen in bodybuilding circles.
• Adding insult to injury, high estrogen levels are suppressive in their own right which can cause delayed progress in the gym when coming off tamoxifen use..
• Studies (9,10) support the notion that tamoxifen can contribute to increasing susceptibility to cataracts.
• A study published in the Journal of Endocrinology(3) showed that long term tamoxifen use increased serum testosterone levels by 50% which is certainly a healthy increase.
• While not everyone gets this it is notable that these effects don’t get reported to anywhere the same extent with other PCT products making it feasible that this occurs as a consequence of the rise in serum estrogen seen during tamoxifen use.

With respect to its action in the brain it inhibits the conversion of testosterone to estrogen which during a cycle can mean that estrogen levels remain low. Although low estrogen is often considered advantageous by bodybuilders it should be noted that estrogen helps both with the accrual of muscle mass and also helps to boost libido on cycle. In fact, when bodybuilders use testosterone enhancing compounds and run tamoxifen alongside it, they often lose out on some of the muscle gains and enhanced libido that normally accompanies testosterone elevation. Although classed as an estrogen antagonist it should be noted that in some parts of the body tamoxifen actually acts as an estrogen agonist meaning it actually acts in an estrogenic manner as opposed to how most think of it being which is an anti-estrogen.

Final thoughts on Tamoxifen for PCT

IGF-1 is broken down from growth hormone and is considered to be more potent than growth hormone itself for the purposes of building muscle tissue. High IGF-1 levels make a big contribution to the process of building a better physique and the ability of tamoxifen to suppress IGF-1 levels is another reason why tamoxifen use tends to be disappointing for the purposes of building muscle mass. It acts as an estrogen antagonist in the brain and the breast area meaning it prevents estrogen from exerting its normal effect in those areas.

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What Does Tamoxifen Do?

A study published in the Journal of Endocrinology(3) showed that long term tamoxifen use increased serum testosterone levels by 50% which is certainly a healthy increase. In fact, in the control group in this study, which only used tamoxifen for a week, estrogen rose after just four days. Considering that the subjects in this trial used tamoxifen at a lower dose of just 10mg it begs the question of what would happen if used at the higher dosagetypically seen in bodybuilding circles.

Tamoxifen is of course frequently used to suppress estrogenic action in breast tissue to prevent gynecomastia for which it can work rather well during cycle. It will not totally eliminate the possibility of gyno though especially with those steroids that act in a progesterogenic fashion for which something that lowers prolactin such as the supplement Vitex will be required. Assuming though that your cycle went well and you ran a PCT and you battled through the suppressed sex drive, low IGF-1 levels and low free testosterone levels seen with tamoxifen usage. If we consider the study above which shows a profound rise in estrogen in the body during tamoxifen use, its removal is going to create a situation where we now have high estrogen levels in the body and with nothing to stop this estrogen from causing gyno in male bodybuilders. This creates a recipe for the kind of rebound gyno that you often hear people complaining about on bodybuilding forums.

Other Health Effects

Adding insult to injury, high estrogen levels are suppressive in their own right which can cause delayed progress in the gym when coming off tamoxifen use.. This helps to explain why we never hear of people using tamoxifen on a standalone basis (similar to how a testosterone booster is used) and gaining any muscle mass despite the significant rise in testosterone it is capable of producing. Another negative of tamoxifen’s action in the liver is its ability to suppress production of the peptide hormone IGF-1.

Mood swings – Perhaps the most common complaint of all from bodybuilders using tamoxifen or other SERM’s during PCT is they cause unbearable mood swings with frequent reports of tearfulness, and depression occurring among bodybuilders. While not everyone gets this it is notable that these effects don’t get reported to anywhere the same extent with other PCT products making it feasible that this occurs as a consequence of the rise in serum estrogen seen during tamoxifen use. Blood Clots – Tamoxifen usage is recognised as increasing the risk of blood clotting which if it occurs in a major artery or cardiac tissue can potentially be life threatening. Liver damage – Tamoxifen has been studied for its effects on liver for some time with it being linked to fatty liver in women (8) as well as showing an increased likelihood in the formation of liver cancer. Cataracts – Tamoxifen is acutely toxic to the eyes with more than one report on a bodybuilding forum showing a user who irreversibly damaged their eyesight. Studies (9,10) support the notion that tamoxifen can contribute to increasing susceptibility to cataracts.